Cytotoxic substances produced by a fungal strain from a sponge: physico-chemical properties and structures.

نویسندگان

  • T Amagata
  • Y Usami
  • K Minoura
  • T Ito
  • A Numata
چکیده

Five novel metabolites, trichodenones A-C (1-3), harzialactone A (4) and B (5), have been isolated together with known R-mevalonolactone (6) from the culture broth of a strain of Trichoderma harzianum OUPS-N115 originally separated from the sponge Halichondria okadai. Their structures have been elucidated by spectral evidence. Among them, 1-3 exhibited significant cytotoxicity against cultured P388 cells.

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عنوان ژورنال:
  • The Journal of antibiotics

دوره 51 1  شماره 

صفحات  -

تاریخ انتشار 1998